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課程名稱 |
分子神經生物學論文選讀
CURRENT TOPICS IN MOLECULAR NEUROBIOLOGY RESEARCH |
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開課學期 |
96-1 |
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授課對象 |
生命科學院 生命科學系 |
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授課教師 |
王致恬 |
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課號 |
MCB5020 |
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課程識別碼 |
B43 U1320 |
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班次 |
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學分 |
1 |
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全/半年 |
半年 |
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必/選修 |
選修 |
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上課時間 |
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上課地點 |
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備註 |
時間地點另定.選課前須經授課老師同意
總人數上限：10人 |
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課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
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課程大綱
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課程概述 |
以討論的方式研讀論文 |
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課程目標 |
學習如何討論論文 |
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課程要求 |
課前預習; 不可無故缺席 |
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預期每週課後學習時數 |
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Office Hours |
另約時間 |
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指定閱讀 |
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參考書目 |
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評量方式
(僅供參考) |
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No. |
項目 |
百分比 |
說明 |
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1. |
討論參與 |
100% |
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週次 |
日期 |
單元主題 |
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第1週 |
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Introduction |
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第2週 |
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Wang CT, Zhang HG, Rocheleau TA, ffrench-Constant RH and Jackson MB. Cation permeability and cation-anion interactions in a mutant GABA-gated chloride channel from Drosophila. Biophysical Journal. 1999 Aug; 77(2): 691-700. |
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第3週 |
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Wang CT, Blankenship A, Anishchenko A, Elstrott J, Fikhman M, Nakanishi S and Feller MB. GABAA receptor-mediated signaling alters the structure of spontaneous activity in the developing retina. The Journal of Neuroscience. 2007 Aug 22; 27(34): 9130-40. |
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第4週 |
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Holiday |
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第5週 |
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Chow RH, von Ren L, Neher E. Delay in vesicle fusion revealed by electrochemical monitoring of single secretory events in adrenal chromaffin cells. Nature. 1992 Mar 5; 356(6364):60-3. |
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第6週 |
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Bruns D and Jahn R. Real-time measurement of transmitter release from single synaptic vesicles. Nature. 1995 Sep 7; 377(6544):62-5. |
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第7週 |
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Albillos A, Dernick G, Horstmann H, Almers W, Alvarez de Toledo G, Lindau M. The exocytotic event in chromaffin cells revealed by patch amperometry.Nature. 1997 Oct 2;389(6650):509-12. |
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第8週 |
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Midterm |
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第9週 |
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Wang CT, Grishanin R, Earles CA, Chang PY, Martin TFJ, Chapman ER and Jackson MB. Synaptotagmin modulation of fusion pore kinetics in regulated exocytosis of dense-core vesicles. Science 2001 Nov 2; 294(5544): 1111-5. |
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第10週 |
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Wang CT, Lu JC, Bai J, Chang PY, Martin TFJ, Chapman ER and Jackson MB. Different domains of synaptotagmin control the choice between kiss-and-run and full fusion. Nature 2003 Aug 21; 424(6951): 943-7. |
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第11週 |
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Han X, Wang CT, Bai J, Chapman ER and Jackson MB. Transmembrane segments of syntaxin line the fusion pore of Ca2+triggered exocytosis. Science 2004 Apr 9; 304(5668): 289-92. |
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第12週 |
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Klyachko VA, Jackson MB. Capacitance steps and fusion pores of small and large-dense-core vesicles in nerve terminals. Nature. 2002 Jul 4; 418(6893):89-92. |
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第13週 |
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Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytes. Zhang J, Hupfeld CJ, Taylor SS, Olefsky JM, Tsien RY. Nature. 2005 Sep 22;437(7058):569-73. |
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第14週 |
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Dunn TA*, Wang CT*, Colicos MA, Zaccolo M, DePilato LM, Zhang J, Tsien RY and Feller MB. Imaging of cAMP levels and protein kinase A activity reveals that retinal waves drives oscillations in second-messenger cascade. The Journal of Neuroscience. 2006 Dec 6; 26(49): 12807-15. (*These authors contributed equally to this work.) |
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第15週 |
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Tojima T, Akiyama H, Itofusa R, Li Y, Katayama H, Miyawaki A, Kamiguchi H. Attractive axon guidance involves asymmetric membrane transport and exocytosis in the growth cone.Nat Neurosci. 2007 Jan;10(1):58-66. Epub 2006 Dec 10. |
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第16週 |
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Holiday |
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第17週 |
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Yin Y, Henzl MT, Lorber B, Nakazawa T, Thomas TT, Jiang F, Langer R, Benowitz LI. Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells. Nat Neurosci. 2006 Jun;9(6):843-52. Epub 2006 May 14. |
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第18週 |
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NULL |
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